White Matter Injury in Premature Newborns.
نویسنده
چکیده
Preterm newborns are highly susceptible to brain injury. White matter injury is among the dominant patterns of brain injury in preterm newborns. the purpose of this review is to discuss the pathogenesis, diagnosis, management, and prevention of white matter injury in premature newborns. the long-term outcome of white matter injury in children born prematurely is also addressed.
منابع مشابه
Serial quantitative diffusion tensor MRI of the premature brain: development in newborns with and without injury.
PURPOSE To determine the change over time of the apparent diffusion coefficient (ADC) and relative anisotropy of cerebral water in a cohort of premature newborns serially studied near birth and again near term. MATERIALS AND METHODS Newborns were classified as normal (N = 11), minimal white matter injury (N = 7), or moderate white matter injury (N = 5). RESULTS ADC decreased significantly w...
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OBJECTIVE The association of chorioamnionitis and noncystic white matter injury, a common brain injury in premature newborns, remains controversial. Our objectives were to determine the association of chorioamnionitis and postnatal risk factors with white matter injury, and the effects of chorioamnionitis on early brain development, using advanced magnetic resonance imaging. METHODS Ninety-tw...
متن کاملWhite Matter Injury of Prematurity: Its Mechanisms and Clinical Features
A developing central nervous system is vulnerable to various insults such as infection and ischemia. While increased understanding of the dynamic nature of brain development allows a deeper insight into the pathophysiology of perinatal brain injury, the precise nature of specific fetal and neonatal brain injuries and their short- and long-term clinical consequences need special attention and fu...
متن کاملDiminished white matter injury over time in a cohort of premature newborns.
OBJECTIVES To determine the rate of magnetic resonance imaging (MRI)-detected noncystic white matter injury (WMI) in a prospective cohort of premature newborns, and to evaluate its associations with changes in clinical predictors of WMI over the study period. STUDY DESIGN A prospective cohort of premature newborns (<33 weeks gestational age) was studied with MRI within 4 weeks of birth and ne...
متن کاملComparing the diagnosis of white matter injury in premature newborns with serial MR imaging and transfontanel ultrasonography findings.
BACKGROUND AND PURPOSE The accurate identification of white matter injury in premature neonates is important for counseling parents and for targeting these high risk neonates for appropriate rehabilitation services. The objective of this study was to compare the diagnosis of white matter injury detected by serial MR imaging and ultrasonography of a contemporary cohort of premature neonates. M...
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ورودعنوان ژورنال:
- Neonatal network : NN
دوره 35 2 شماره
صفحات -
تاریخ انتشار 2016